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Funct. Mater. 2016; 23 (1): 049-054.


Fractal dimension of the breast cancer cells resistant and sensitive to doxorubicin activity

O.Medviediev1, O.Yu.Gorobets1, V.F.Chekhun2, S.V.Gorobets1, I.V.Demyanenko1, K.O.Butenko1

1 National Technical University "Kyiv Polytechnic Institute", 37 Prospect Peremogy, 03056 Kyiv, Ukraine
2 R.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, 45 Vasylkivska St., 03022 Kyiv, Ukraine


The main purpose of this research is examining and comparing of the fractal dimension (FD) and quantity of biogenic magnetic nanoparticles (BMN) of the resistant and sensitive MCF-line breast cancer cells to doxorubicin activity. The FD of boundaries of sensitive cells is greater than the FD of the boundaries of resistant cells. The quantity of BMN per one cell in sensitive and resistant cells do not differ. The FD of the cell boundaries can be an additional marker for the determination of cell sensitivity to the doxorubicin activity. The part of the tumor cell surface containing one BMN can be also the potential marker for the determination of the sensitivity to the doxorubicin action as well.

fractal dimension; doxorubicin; MCF-line breast cancer cells; BMN.

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