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Funct. Mater. 2017; 24 (4): 577-583.

doi:https://doi.org/10.15407/fm24.04.577

Adsorption of ceftriaxon by biogenic hydroxyapatite with magnetic additions

O.M.Otychenko1,2, T.Ye.Babutina1, O.A.Kuda1, O.M.Budylina1, L.S.Protsenko1, O.Yu.Koval1, I.V.Uvarova1,2

1Frantsevich Institute for Problems of Materials Science, 3 Krzhizhanovsky Str., 03680 Kyiv-142, Ukraine
2National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute", 37 Peremogy Ave., 03056 Kyiv, Ukraine

Abstract: 

The possibility of using nanoporous composite system based on biogenic hydroxyapatite (BHA), which alloyed by ferromagnetic additives due to using two methods of physicochemical mixing, as a carrier of drugs for orthopedics and traumatology was shown. It was found that the sample obtained by precipitation previously prepared iron oxalate on the surface of BHA microspheres has a greater adsorption activity than the sample obtained by including BHA directly in the process of obtaining iron oxalate (300 and 175 mg/g respectively). However, due to the difference in porosity, they are capable to hold a different amount of the injected antibiotic mass: 6 mass.% - for material obtained by physico-mechanical method and 10 mass.% - for the sample obtained by chemical method.

Keywords: 
biogenic hydroxyapatite, alloying, adsorption activity, бeftriaxon.
References: 

1. I.Rajzer, E.Menaszek, R.Kwiatkowski et al., J. Mater.Sci:Mater.Med., 25, 1239 (2014). https://doi.org/10.1007/s10856-014-5149-9

2. J.Michel, M.Penna, J.Kochen et al., Stem Cells Int., (2015), DOI: 10.1155/305217.

3. V.Campana, G.Milano, E.Pagano et al., J. Mater. Sci:Mater. Med., 25, 2445 (2014). https://doi.org/10.1007/s10856-014-5240-2

4. S.M.Barinov, V.S.Komlev, Nauka v Rossii, 1, 27 (2005).

5. N.A.Korzh, L.A.Kladchenko, S.V.Malyshkina, Ortopediya, Travmatologia i Protezirovanie, 4, 5 (2008).

6. V.I.Putliaev, Sorosovkii Obrazovatel'niy Zhurnal, 1, 45 (2004).

7. L.Ryden, O.Omar, A.Johansson et al., J. Mater. Sci:Mater. Med., 28, 9 (2017). https://doi.org/10.1007/s10856-016-5814-2

8. V.A.Dubok, V.V.Protsenko, A.V.Shynkaryk et al., Ortopediya, Travmatologia i Protezirovanie, 3, 91 (2008).

9. S.A.Filatov, H.S.Kuchinskiy, D.M.Lale et al., in: Int. Sci. Conf. NANSYS-2012, Kyiv, Ukraine (2012) [in Russian].

10. Q.Li, G.Zhou, T.Wang et al., J. of Nanomater., (2015), DOI: 10.1155/835604.

11. N.V.Boshitskaya, Powder Metallurgy, 11/12, 3 (2010).

12. S.V.Gorobets, O.Yu.Gorobets, Functional Materials, 19, 18 (2012).

13. P.P.Gorbyk, V.F.Chekhun, Functional Materials, 19, 145 (2012).

14. A.Akbarzadeh, M.Samiei, S.Davaran, Nanoscale Research Letters, 7, 144 (2012). https://doi.org/10.1186/1556-276X-7-144

15. A.V.Razumovskiy, Ratsionalnaya Antibiotikoprofilaktika v Travmatologii i Ortopedii, Moscow (2009) [in Russian].

16. N.V.Ul'yanchich, E.A.Ivaschenko, I.V.Uvarova et al., Ukr. Morph. Al'manah, 8, 44 (2010).

17. O.A.Ivaschenko, Nanostrukturnoe Materialovedenie, 2, 58 (2012).

18. Ya-J.Guo, T.Long, W.Chen et al., Mater. Science and Engineering C, 33, 3583 (2013). https://doi.org/10.1016/j.msec.2013.04.021

19. D.Loca, M.Sokolova, J.Locs et al., Mater. Science and Engineering C, 49, 106 (2015). https://doi.org/10.1016/j.msec.2014.12.075

20. V.I.Cherniy, A.N.Kolesnikov, I.V.Kuznetsova et al., Novosti Mediciny i Farmatsii, 343, 1 (2010).

21. A.K.Rushai, V.T.Shevchenko, V.H.Pernakova et al., Travma, 2, 1 (2010).

22. V.T.Shevchenko, V.H.Pernakova, E.N.Poddubnaya, Travma, 3, 1 (2010).

23. E.M.Khodosh, Novosti Mediciny i Farmatsii Antimikrobnaya i Protivovirusnaya Terapiya, 310, 1 (2010).

24. UA Patent 61938 (2003).

25. UA Patent 26584 (1999).

26. O.M.Otychenko, T.E.Babutina, O.R.Parkhomey et al., Chem. Phys. and Technol. of Surf., 1, 10 (2017).

27. V.V.Panichkina, I.V.Uvarova, Methods for Controlling the Dispersion and the Specific Surface Area of Metallic Powders, Naukova Dumka, Kyiv (1973) [in Russian].

28. O.A.Tyazhelov, N.O.Ashukina, H.V.Ivanov et al., Ortopediya, Travmatologia i Protezirovanie, 4, 47 (2006).

29. N.V.Kerymkulova, I.Yu.Torshin, O.A.Gromova et al., Reproductivnaya Endokrinologiya, 4, 101 (2013). https://doi.org/10.18370/2309-4117.2013.12.101-110

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