Funct. Mater. 2017; 24 (4): 577-583.
Adsorption of ceftriaxon by biogenic hydroxyapatite with magnetic additions
1Frantsevich Institute for Problems of Materials Science, 3 Krzhizhanovsky Str., 03680 Kyiv-142, Ukraine
2National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute", 37 Peremogy Ave., 03056 Kyiv, Ukraine
The possibility of using nanoporous composite system based on biogenic hydroxyapatite (BHA), which alloyed by ferromagnetic additives due to using two methods of physicochemical mixing, as a carrier of drugs for orthopedics and traumatology was shown. It was found that the sample obtained by precipitation previously prepared iron oxalate on the surface of BHA microspheres has a greater adsorption activity than the sample obtained by including BHA directly in the process of obtaining iron oxalate (300 and 175 mg/g respectively). However, due to the difference in porosity, they are capable to hold a different amount of the injected antibiotic mass: 6 mass.% - for material obtained by physico-mechanical method and 10 mass.% - for the sample obtained by chemical method.
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