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Funct. Mater. 2017; 24 (4): 660-666.

doi:https://doi.org/10.15407/fm24.04.660

Poly(lactic acid) scaffolds modified by gelatin for the controlled release of tetrandrine in vitro

Zhang Ye1,2

1 Department of Pharmaceutical Sciences, Zibo Vocational Institute, Zibo, Shandong 255314, China
2 Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

Abstract: 

To mimic natural extracellular matrix architecture, tetrandrine-loaded poly(L-lactic acid) scaffolds modified by gelatin were prepared via phase separation, solvent replacement and freeze-drying. The purpose of this work was to combine the biological effects of tetrandrine and the advantages of poly(L-lactic acid) scaffolds which was modified by gelatin to enhancing the mass transfer features of controlled release systems. Tetrandrine contained in the scaffolds was confirmed by X-ray photoelectron spectroscopy (XPS) and Fourier-transform infrared (FT-IR) spectroscopy. Tetrandrine did not change the morphous, crystallinity and thermodynamics of the scaffolds which demonstrated by differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and X-ray powder diffractometry (XRD). The results of this study showed a sustained release with 79.15% for 188 days in vitro.

Keywords: 
poly(lactic acid) scaffolds, gelatin, tetrandrine, tissue engineering.
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