Funct. Mater. 2018; 25 (3): 432-438.
Effects of different concentrations of sodium ions on the self-assembly of amphotericin B and DPPC at the air-water interface
1 Shaanxi Engineering Research Center of Controllable Neutron Source, Xijing University, Xi'an, 710123, China
2 School of Electronic Information Engineering Internet of Things and Big Data Research center, Xijing University, Xi'an, 710123, China
3 The Fourth Military Medical University, Xi'an, 710032,China
4 Department of Science, Xijing University, Xi'an, 710123, China
Amphotericin B is a widely used polyene antifungal drug for the treatment of deep fungal infections. This drug could cause pores on the cell membrane. In this work, we used the dipalmitoylphosphatidylcholine monolayer as the model of cell membrane in half. The influence of Na+ions on the interaction between amphotericin B and biomembrane were studied by analysis of phase transition and thermodynamic properties of monolayers. The Na+ions may affect the molecular orientation of amphotericin B, and it depends on the concentration of sodium ions. Low concentration of Na+ ions has an opposite effect to high concentration of that. The results are helpful for obtaining some information on the influence mechanism in the level of sodium ions on the interaction between amphotericin B and biomembrane in the angle of physics.
1. Dynarowicz-Latka P, Minoes Jr. J, Conde O, et al., Appl. Surf. Scien., 246, 334, 2005. https://doi.org/10.1016/j.apsusc.2004.11.037
2. Ganrrignes J C, Ricco-Lattes I, Perez E, et al. Langmuir, 14, 5968, 1998. https://doi.org/10.1021/la980460u
3. Ermishkin L N, Kasumov K M, Potzeluyev, Nature, 262, 698, 1976. https://doi.org/10.1038/262698a0
4. Andreoli T E. Annals New York Acad Scien, 235, 448, 1974. https://doi.org/10.1111/j.1749-6632.1974.tb43283.x
5. Katsu T, Okada S, Imamura T, et al., Anal. Scien, 24, 1551, 2008 . https://doi.org/10.2116/analsci.24.1551
6. Gagos M, Arczewska M., J Phys Chem B, 115, 3185, 2011. https://doi.org/10.1021/jp110543g
7. Becucci L, Innocenti M, Bellandi S, et al., Electrochim Acta, 112, 719, 2013. https://doi.org/10.1016/j.electacta.2013.09.027
8. Turcu R, Patterson M J, Omar S., Pediatric Nephrology, 24, 497, 2009. https://doi.org/10.1007/s00467-008-1050-4
9. Zakanda F N, Laurent P, Paquot M, et al. Thin Solid Films, 520, 344, 2011. https://doi.org/10.1016/j.tsf.2011.07.005
10. Wang J, Sun R G, Hao C C., Scien China Chem, 57, 1538, 2014. https://doi.org/10.1007/s11426-014-5124-9
11. Nakahara H, Nakamura S, Okahashi Y, et al., Colloids Surfaces B- Biointerfaces, 102, 472, 2013. https://doi.org/10.1016/j.colsurfb.2012.08.031
12. Gzyl-Malcher B, Handzlik J, Klekowska E. Bioelectrochem, 87, 96, 2012. https://doi.org/10.1016/j.bioelechem.2011.12.005
13. Wang J, Shi R X, Sun R G, et al. Chin Phys B, 25, 090505, 2016. https://doi.org/10.1088/1674-1056/25/9/090505
14. Panda A K, Wojciechowski P, Nag S, et al. J Display Techn, 30, 1255, 2009. https://doi.org/10.1080/01932690902735124
15. Wang J, Sun R G, Hao C C, et al., Chem Research Chine Univ, 33, 447, 2017. https://doi.org/10.1007/s40242-017-6303-y