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Funct. Mater. 2019; 26 (4): 845-849.

doi:https://doi.org/10.15407/fm26.04.845

Degradation of three dimensional poly(l-lactic acid) scaffolds modified by gelatin

Ye Zhang1, Hong-ming Liu2

1Department of Pharmaceutical Sciences, Zibo Vocational Institute, Shandong, 255314 Zibo, China
2Zibo Institute for Food and Drug Control, Shandong, 255086 Zibo, China

Abstract: 

In vitro degradation of poly(l-lactic acid) (PLLA) scaffolds modified by gelatin was carried out in 0.01 M NaOH solution at 37°C for 5-6 days. The mass loss, pH value, viscosity-average molecular weight, morphology and thermal behavior during degradation were studied. The results showed that the prepared scaffolds were interpenetrating porous structure and the increased degradation time; both the viscous-average molecular weight and melting peak showed a clear upward trend, while the crystallinity and mass loss exhibited a downward trend. The semi-logarithmic linear relationship between the viscosity-average molecular weight and degradation time indicates an autocatalytic process. The mass of the PLLA scaffolds decreased by 10.33 % after 2 days of degradation and decreased by 86.19 % to the end of the experimental period. The decrease in the viscous-average molecular weight and a relatively little mass loss in the beginning of the degradation period indicate the bulk degradation. The gradual mass loss is indicated not only by the bulk degradation mechanism but also a surface erosion mechanism. The results obtained by the in vitro degradation in a NaOH solution at 37°C can find useful applications in solving the biocompatibility of PLLA scaffolds.

Keywords: 
Poly(l-lactic acid), scaffolds, degradation, tissue engineering, gelatin.
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