Funct. Mater. 2021; 28 (3): 525-532.
A microscopic model of drugs penetration into lipid membranes
1Institute for Single Crystals, STC "Institute for Single Crystals", National Academy of Sciences of Ukraine, 60 Nauky Ave., 61072 Kharkiv, Ukraine
2V.N.Karazin Kharkiv National University, 4 Svobody Sq., 61022 Kharkiv, Ukraine
3Institute for Scintillation Materials, STC "Institute for Single Crystals", National Academy of Sciences of Ukraine, 60 Nauky Ave., 61072 Kharkiv, Ukraine
The problem of interactions between complex ordered media and admixture molecules is a challenge of modern material science. In the case of interactions between lipid membrane medium and drugs, the problem gains important biological sense. The present work is aimed to develop a microscopic model for characterization drug penetration into lipid bilayer membrane. The model considers the balance between elastic ("drowing out") and dispersion ("drowing in") components of "membrane - drug" interactions which defines the equilibrium depth of drug penetration and describes properly such features as penetration to a certain depth, accumulation of drug molecules at the center of the membrane, as well as the absence of penetration. It helps to establish common physical basis of a set of experimental results obtained for these systems, including V-shape dependences "membrane melting temperature vs. the depth of penetration" as well as "specific membranotropic effect of a drug molecule vs. its lipophilicity", etc.
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