Funct. Mater. 2022; 29 (4): 553-558.


Modeling of processes of solvent diffusion from ointment bases using in vitro experiments

O.P.Bezugla, M.O.Lyapunov, I.O.Zinchenko, O.A.Lisokobilka, A.M.Liapunova

STC "Institute for Single Crystals", National Academy of Sciences of Ukraine, 60 Nauki Ave., 61072 Kharkiv, Ukraine


The results of the study of the release of propylene glycol (PG) and macrogol 400 (M400) from a water-soluble ointment base and the absorption of water by this base in vitro experiments through a semipermeable membrane using vertical diffusion chambers are presented. The content of hydrophilic solvents in the dialysate from 0.5 to 6.0 h of the experiment was determined by the gas chromatography method, calculated per cm2 of the membrane area. Parameters such as release rate, cumulative content, dialysate concentration, and percentage of selvent realeased (after 6 h) were calculated. It is shown that the diffusion of PG through a semipermeable membrane is much more intense than the diffusion of M400, which is primarily due to its lower molecular weight. Ointment base absorbs water due to high-molecular macrogols and poloxamer, which do not penetrate through the membrane. Based on the results of the research, it can be predicted that the introduction of a low-molecular-weight solvent into the ointment base will eliminate the non-specificity of the dehydrating effect of the ointment base in vivo. The ointment base will ensure the absorption of purulent exudate in the absence of a dehydrating effect on viable tissues.

propylene glycol, macrogol 400, ointment base, release.
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