Funct. Mater. 2022; 29 (4): 553-558.

The results of the study of the release of propylene glycol (PG) and macrogol 400 (M400) from a water-soluble ointment base and the absorption of water by this base in vitro experiments through a semipermeable membrane using vertical diffusion chambers are presented. The content of hydrophilic solvents in the dialysate from 0.5 to 6.0 h of the experiment was determined by the gas chromatography method, calculated per cm² of the membrane area. Parameters such as release rate, cumulative content, dialysate concentration, and percentage of selvent realeased (after 6 h) were calculated. It is shown that the diffusion of PG through a semipermeable membrane is much more intense than the diffusion of M400, which is primarily due to its lower molecular weight. Ointment base absorbs water due to high-molecular macrogols and poloxamer, which do not penetrate through the membrane. Based on the results of the research, it can be predicted that the introduction of a low-molecular-weight solvent into the ointment base will eliminate the non-specificity of the dehydrating effect of the ointment base in vivo. The ointment base will ensure the absorption of purulent exudate in the absence of a dehydrating effect on viable tissues.