Funct. Mater. 2023; 30 (2): 187-196.


Features of the apatite-like layer formation on the surface of bioactive glass-ceramic materials in vivo

Oksana Savvova1, Oleksii Fesenko1, Olena Babich2, Hennadii Voronov1, Yuliia Smyrnova1

1O.M.Beketov National University of Urban Economy in Kharkiv, 17 Marshal Bazhanov Str., 61002 Kharkiv, Ukraine
2Ukrainian Scientific Research Institute of Ecological Problems, 6 Bakulina Str., 61166 Kharkiv, Ukraine


Strengthened bioactive glass-ceramic materials based on hydroxyapatite and lithium disilicate with high crack resistance, corresponding to bone tissue, have been developed. The features of the formation of an apatite-like layer on the surface of bioactive glass-ceramic materials in vivo, namely, the intensification of the nucleation and growth of calcium phosphate crystals due to the developed surface structure, have been established. It has been established that the formation of a crystallized structure of a glass-ceramic material based on nano- and submicron crystals of hydroxyapatite and lithium disilicate in an amount of 50 and 10 vol. %, respectively, can provide its high strength (flexural strength 180 MPa, crack resistance index 6.0 MPa·m1/2) and bioactivity (presence of accumulations of hydroxyapatite crystals). It is these indicators that are a necessary condition for the accelerated formation of a strong apatite-like layer on the surface of prototypes in the environment of a living organism. The active formation of bone tissue on the surface of lithium calcium silicate glass-ceramic materials was confirmed by biochemical markers. The results obtained can be used in the development of bioactive glass-ceramic materials with shortened resorption periods up to one month for the replacement of bone defects.

lithium calcium silicate glass-ceramic materials, hydroxyapatite, lithium disilicate, crack resistance, apatite-like layer, biochemical markers.

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