Funct. Mater. 2025; 32 (3): 348-360.

The relevance of the development of biomedical materials science in the direction of creating biomimetic functional materials is analyzed. Promising directions for the use of glass-ceramic materials for biomedical purposes have been identified, allowing the formation of a dissipative structure that self-organizes into heteronanodomains during a solid-phase reaction. The influence of micro- and macroelements on the formation of bone tissue has been established and their choice in the development of bioactive glass-ceramic materials as cofactors for the self-organization of biological structures based on biomineralization has been substantiated.The compositions of glass-ceramic materials based on the Na₂O–K₂O–Li₂O–CaO–ZrO₂– TiO₂–MgO–ZnO–Al₂O₃–B₂O₃–P₂O₅–Nb₂O₅–SiO₂ system in the area of metastable liquation have been developed. They are characterized by the ratio of CaO/P₂O₅ = 1.67–1.7 and SiO₂/Li₂O = 4 and the total content of modifying components of 1.7–3.5 wt. %. The mechanism of phase formation of the developed glasses during low-temperature rapid heat treatment has been established; it consists in the self-organization of clusters based on sybotaxic groups formed in the glass melt during melting, their ordering into nanostructures and the formation of a sitallized structure. The developed high-strength bioactive glass-ceramic materials contain the main crystalline phases (calcium phosphate, lithium aluminosilicates, lithium disilicate, lithium phosphate, diopside) in the amount of 90–95 vol.%, that simultaneously ensures high bioactivity, strength and the ability to form a crack-resistant structure due to nanostructuring, dendritic reinforcement and the exclusion of thermal effects during synthesis.