Funct. Mater. 2026; 32 (1): 46-53.
Novel Na+,Mg2+(Cu2+),CO32-/(BO33-,BO2-)-substituted hydroxyapatites/CuFe2O4 composites: synthesis and investigation
1 Taras Shevchenko National University of Kyiv, Volodymyrska Str. 64/13, 01601 Kyiv, Ukraine
2Igor Sikorsky Kyiv Polytechnic Institute, Peremohy av., 37, 03056, Kyiv, Ukraine
3Enamine Ltd, 78, Winston Churchill Str., 02094, Kyiv, Ukraine
4Zabolotny Institute of Microbiology and Virology, NAS of Ukraine, 154, Akademika Zabolotnogo St., 03143, Kyiv, Ukraine
Calcium phosphates modified with complexes of ions Na+,Mg2+,Cu2+,CO32-/ (BO33-BO2-) or Na+,Mg2+,Cu2+,Fe3+,CO32-/(BO33-,BO2-), as well as composites based on calcium phosphate containing Na+,Mg2+,CO32-/(BO33-,BO2-) and (10 or 25 wt%) CuFe2O4 have been obtained from the aqueous solution and further heated to 600°C. It was found that borate-ions in the initial solutions allowed stabilization of the apatite-type phase, whereas in the case of a carbonate-containing system a biphasic calcium phosphate was obtained in composite with 25 wt% CuFe2O4. Systems containing carbonates produced larger particles (28-34 nm) than borate-containing systems (range 19-23 nm). The presence of different types of anions (PO43-, CO32-, BO33-, BO2, OH-) was confirmed by FTIR spectroscopy. Composites based on biphasic calcium phosphate with 25 wt% CuFe2O4 demonstrated higher activity with respect to partial dissolution in the model solution compared to modified calcium phosphates and composites based on them with CuFe2O4. The highest antibacterial properties against S. aureus or P. aeruginosa strains were found for borate-containing apatite. Obtained results can be important in the creation of materials with special bioactivity and antibacterial properties for medical application.
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